GO/TiO<sub>2</sub> Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells
| Author | Atieh Karbalaei | en |
| Author | Zahra Mohammadalipour | en |
| Author | Marveh Rahmati | en |
| Author | Alireza Khataee | en |
| Author | Mohammad Amin Moosavi | en |
| Issued Date | 2017-03-31 | en |
| Abstract | Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO2 hybrid (GOT) NPs as new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while different concentrations of GOT NPs (1 - 100 μg/mL) were inert, their irradiation with visible-light induced growth arrest and cell death in A375 cells in a dose-despondent manner. These anti-cancer effects were accompanied by significant morphological changes, suggesting GOT NPs have a potential for further evaluation as new generation of PSs for cancer therapy. | en |
| DOI | https://doi.org/10.5812/jssc.63984 | en |
| Keyword | A375 Cells | en |
| Keyword | Graphene Oxide/Titanium Dioxide | en |
| Keyword | Melanoma | en |
| Keyword | Photodynamic Therapy | en |
| Publisher | Brieflands | en |
| Title | GO/TiO<sub>2</sub> Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells | en |
| Type | Research Article | en |