Effect of Oral Clonidine on Shoulder Tip Pain and Hemodynamic Response After Laparoscopic Cholecystectomy: A Randomized Double Blind Study
| Author | Hamid Mirhosseini | en |
| Author | Mohamad Hossein Avazbakhsh | en |
| Author | Meysam Hosseini Amiri | en |
| Author | Ahmad Entezari | en |
| Author | Reza Bidaki | en |
| Orcid | Reza Bidaki [0000-0002-5482-9143] | en |
| Issued Date | 2017-12-30 | en |
| Abstract | Background: Shoulder tip pain is a common problem after laparoscopic cholecystectomy. There are a few clinical trial studies on the effect of clonidine on post laparoscopic shoulder pain (PLSP). This study aimed at evaluating the effect of oral clonidine on PLSP in semi-sitting position and post-operative hemodynamic response of patients undergoing LC surgery. Methods: This randomized controlled clinical trial was conducted on 60 patients, who were candidates for elective laparoscopic cholecystectomy surgery under general anesthesia, and were randomly allocated to clonidine and placebo groups. Patients in the clonidine group received 0.2 mg oral, 90 minutes prior to induction. Patients in the placebo group received vitamin C tablets during the same time. Postoperative pain intensity was assessed, using a visual analog scale at the emergence from anesthesia, 4 and 8 hours after the operation by an anesthetist, who was blinded to the patient group. Mean arterial blood pressure and heart rate were recorded before clonidine administration and in post-operative period. Results: The mean age was 36.85 ± 10.93 years and the mean Body Mass was 26.34 ± 3.46 kg/m2. Two groups were not comparable with respect to occurrence of PLSP (P = 0.739). There was a significant difference in intensity of PLSP between the 2 groups at emergence from anesthesia (P = 0.012), 4 and 8 hours after the operation (P = 0.001) between 2 groups. The clonidine group showed a larger reduction of pain intensity at these phases. The result of independent t test indicated significant differences in the MABP value between the 2 groups at the time of emergence from anesthesia (P = 0.031). The clonidine group demonstrated a lower MABP level at this time. Conclusions: Oral clonidine is not effective in preventing the PLSP. However, it alleviates PLSP intensity in the patient under LC procedure on the first post-operative hours. | en |
| DOI | https://doi.org/10.5812/aapm.61669 | en |
| URI | https://brieflands.com/journals/aapm/articles/61669 | en |
| Keyword | Clonidine | en |
| Keyword | Post-Operative Period | en |
| Keyword | Acute Pain | en |
| Keyword | Hemodynamics | en |
| Keyword | Laparoscopy | en |
| Publisher | Brieflands | en |
| Title | Effect of Oral Clonidine on Shoulder Tip Pain and Hemodynamic Response After Laparoscopic Cholecystectomy: A Randomized Double Blind Study | en |
| Type | Research Article | en |
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