Rapid Virological Response Represents the Highest Prediction Factor of Response to Antiviral Treatment in HCV-Related Chronic Hepatitis: a Multicenter Retrospective Study
| Author | Alessandro Federico | en |
| Author | Mario Masarone | en |
| Author | Marco Romano | en |
| Author | Marcello Dallio | en |
| Author | Valerio Rosato | en |
| Author | Marcello Persico | en |
| Issued Date | 2015-06-01 | en |
| Abstract | Background: Standard [i.e. pegylated interferon (Peg-IFN) + ribavirin] treatment of hepatitis C virus (HCV)-related chronic hepatitis is associated with a sustained virological response (SVR) in 50 - 90% of patients. A rapid virological response (RVR) (i.e. negative HCV-RNA after 4 weeks of treatment) predicts SVR in almost 90% of patients. Objectives: The main aim of this study was to assess the strength of RVR, as a predictive factor of antiviral treatment response. Patients and Methods: Using univariate and multivariate analysis, we retrospectively evaluated biochemical, metabolic, genetic and viral variables that might affect both RVR and SVR to Peg-IFN plus ribavirin, in 315 consecutive outpatients affected by HCV-related chronic hepatitis. Results: At univariate analysis, staging, body mass index, RVR, genotype and viral load were significantly related to SVR (P < 0.001). At multivariate analysis, RVR and genotype remained significant (P < 0.00001). The RVR had a predictive value of 83%. At univariate and multivariate analyses, diabetes (P = 0.003), genotype 2 (P = 0.000) and HCV-RNA values (P = 0.016) were independent predictors of RVR, even though at multivariate analyses, only genotype 2 was significantly related to RVR. When we stratified patients, according to genotype, no laboratory or clinical factors were predictive of RVR in genotype 1 patients at either univariate or multivariate analysis. In genotype 2 patients, staging (P = 0.029) and diabetes (P = 0.001) were the only significant predictors of RVR at univariate analyses, whereas no factor was independently related to RVR, at multivariate analysis. Conclusions: The RVR is the strongest factor of SVR and infection with HCV genotype 2 is significantly associated with RVR. Neither biochemical and/or metabolic factors seem to exert influence on RVR. | en |
| DOI | https://doi.org/10.5812/hepatmon.15(6)2015.18640 | en |
| Keyword | Antiviral Agents | en |
| Keyword | Hepatitis C | en |
| Keyword | Pegylated Interferon SA | en |
| Keyword | Retrospective Studies | en |
| Keyword | Ribavirin | en |
| Publisher | Brieflands | en |
| Title | Rapid Virological Response Represents the Highest Prediction Factor of Response to Antiviral Treatment in HCV-Related Chronic Hepatitis: a Multicenter Retrospective Study | en |
| Type | Research Article | en |
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