Effect of Endurance Training with Royal Jelly on CRP Gene Expression in Muscle Tissue of Rats with Alzheimer ’s Disease

Abstract

Background: Studies have shown that Alzheimer’s disease (AD) causes neuromuscular dysfunction by damaging different parts of the central nervous system and inflammation that can increase C-reactive protein (CRP) levels. Nevertheless, the beneficial effects of endurance training (ET) and royal jelly (RJ) on inflammation and reduction of CRP are not fully elucidated. Objectives: The aim of this research was to investigate the effect of ET with RJ on gene expression of CRP in muscle tissues of rats with AD. Methods: In this experimental study, 24 rats with AD (8 mg/kg trimethyltin injection) were randomly divided into four groups of 1-ET, 2-ET + [RJ (100 mg/kg)], 3-RJ and 4-control. Also, six healthy rats were placed in the healthy control group to investigate the effects of AD induction on CRP gene expression. Endurance training groups performed endurance training with a speed of 15 - 20 m/min, 5 sessions per week for eight weeks. Results: Our findings showed ET and RJ significantly decreased CRP gene expression in muscle tissues of rats with AD (P = 0.001) as well as the interaction of ET and RJ was significant in reducing CRP gene expression in muscle tissues of rats with AD (P = 0.001). Conclusions: It appears that ET and RJ have interactive effects on the reduction of CRP in muscle tissues of rats with AD.