Effects of Biochemical and Hormonal Parameters on the QUS Parameters and Comparison of it with Their Effects on DXA

Abstract

QUS (Quantitative Ultrasound) is noticed as a method for measurement of qualitative characteristics of bone. We assessed the effects of Ca, P, Alk Phos, PTH and vit D on parameters of QUS of heel (SOS, BUA and SI) and compared them with effects of above parameters on DXA results. In 211 normal individual (127 women and 44 men) enrolled in the IMOS study (Iranian serum Ca, P.Alk Phos PTH and vit D was obtained )Multi center Osteoporosis Study and Ca corrected with albumin .After that QUS of heel and BMD of spinal and femoral region was done .The mean of age of women and men was respectively 47.7± 12.1 and 43.4± 15.6. 29% of women were menopause. There was no relation between serum parameters and menopausal status ( Alk Phos had a weak relationship with menopausal status). Ca, P, PTH and Vit D showed no significant relation with BMD of spinal region and femoral neck, SOS (Speed of sound) and SI (Stiffness Index) . Vit D and BUA (Broadband Ultrasound Attenuation) had a weak relation. Alk Phos had a weak relationship with BMD in different regions, SOS, BUA and SI. We conclude that QUS parameters and BMD of spin a and femoral region are not affected by serum biochemical and PTH and Vit d status.