Effect of fenofibrate on plasma level of BDNF and brain oxidative stress markers in pentylenetetrazole-induced kindling seizure in mice
| Author | Nahid Sarahian | en |
| Author | Mohammad Taghi Mohammadi | en |
| Author | Shima Shahyad | en |
| Author | Mohsen Rezaei | en |
| Orcid | Shima Shahyad [0000-0002-5483-5367] | en |
| Issued Date | 2021-10-31 | en |
| Abstract | Introduction: The neuroprotective effect and pleiotropic functions of PPARĪ± agonists (peroxisome proliferator activated receptor-alpha) such as fenofibrate and bezafibrate have been demonstrated by the previous studies. The current study evaluated the antiepileptic effects and neuroprotective functions of fenofibrate in pentylenetetrazole (PTZ)-induced kindling seizure in mice. Materials and Methods: Adult male NMRI mice were randomly assigned into three groups (n=8): Control, untreated kindled mice and fenofibrate-treated kindled animals. Repeated intraperitoneal injections of PTZ (45 mg/kg) once every 48 hours were used to develop the kindling seizure for 21 days. Treated mice were administered orally fenofibrate at doses of 30 mg/kg/day. Plasma level of brain-derived neurotrophic factor (BDNF), brain level of malondialdehyde (MDA) and histopathological changes were evaluated at termination of the study. Results: Fenofibrate administration considerably improved the seizure latency in treated kindled mice. Fenofibrate significantly (P | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/koomesh/articles/153296 | en |
| Keyword | Fenofibrate | en |
| Keyword | Status epilepticus | en |
| Keyword | Neuroprotection | en |
| Keyword | Brain-Derived Neurotrophic Factor | en |
| Keyword | Malondialdehyde | en |
| Keyword | ŁŁŁŁŪŲØŲ±Ų§ŲŖ | en |
| Keyword | ŲµŲ±Ų¹ Ł Ų³ŲŖŁ Ų± | en |
| Keyword | Ł ŲŲ§ŁŲøŲŖ Ų¹ŲµŲØŪ | en |
| Keyword | ŁŲ§Ś©ŲŖŁŲ± ŁŁŲ±ŁŲŖŲ±ŁŁŪŚ© Ł Ų“ŲŖŁ Ų“ŲÆŁ Ł ŲŗŲ²Ū | en |
| Keyword | Ł Ų§ŁŁŁāŲÆŪāŲ¢ŁŲÆŁŪŲÆ | en |
| Publisher | Brieflands | en |
| Title | Effect of fenofibrate on plasma level of BDNF and brain oxidative stress markers in pentylenetetrazole-induced kindling seizure in mice | en |
| Type | Research Article | en |