Potential Neuroprotective Effect of Apis dorsata Honey Against Morphine Tolerance: An in-vivo Study
| Author | nur husna zakaria | en |
| Author | Nasir Mohamad | en |
| Author | Nor Hidayah Abu Bakar | en |
| Author | Siti Norhajah Hashim | en |
| Author | Halim Shariff | en |
| Author | Liyana Hazwani Mohd Adnan | en |
| Issued Date | 2021-09-30 | en |
| Abstract | Background: To determine the effects of Apis dorsata honey on the development of morphine tolerance and oxidative stress in rats. Materials and Methods: A total of 40 male Sprague Dawley rats were injected (subcutaneous) with 10 mg/kg of morphine following oral administration of A. dorsata honey (0.5, 1.5, and 2.5g/kg). On day 15, the rats were euthanized, and the thalamus, spinal cord, and hippocampus were homogenized to assess iNOS and MDA using ELISA kits.Results: The honey of A. dorsata significantly prevented morphine tolerance to analgesia in the hotplate test on Day 14 (p | en |
| DOI | https://doi.org/10.22037/jcma.v6i3.35252 | en |
| Keyword | A. dorsata honey | en |
| Keyword | morphine tolerance | en |
| Keyword | oxidative stress | en |
| Publisher | Brieflands | en |
| Title | Potential Neuroprotective Effect of Apis dorsata Honey Against Morphine Tolerance: An in-vivo Study | en |
| Type | Original Articles | en |