Study One-Pot Synthesis of Nanoparticles Omeprazole-Silver and Omeprazole Sulfide-Silver and Their Antibacterial Properties

Abstract

Background: One of the major advances in the application of nanoparticles is the recognition of steric stabilization, which can enhance particle stability in biological environments and provide opportunities for the development of drug delivery systems (DDSs) aimed at achieving drug targeting and controlled drug release. Nanocrystalline silver particles (AgNPs) have significant applications in biomolecular recognition, antimicrobial treatment, catalysis, and sensor manufacturing. Nanoparticles are utilized in various medical applications, including image quality enhancement, medicine, tissue engineering, and magnetic resonance imaging (MRI) of targeted tissues and cell types. Nanocrystalline silver particles, in particular, significantly contribute to a wide range of industrial and medical applications. Objectives: In this study, the green synthesis of one-pot reaction AgNPs with omeprazole (OMP) and omeprazole sulfide (OMPS) was investigated for their antibacterial properties. Methods: The synthesis of OMP and OMPS drugs was completed on AgNPs, and the resulting nanoparticles were characterized using transmission electron microscopy (TEM), diffuse reflectance spectroscopy (DRS), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Results: Briefly, the size of OMP nanoparticles is less than 40 nm, and the length of OMPS nanoparticles is less than 60 nm. Omeprazole@AgNPs (Ag@OMP) and omeprazol sulfide@AgNPs (Ag@OMPS) can repel bacteria. In the UV-Visible (UV-Vis) spectrum, it has been observed that pure OMPS appear with a λmax at 400 nm, corresponding to the n→π* transition of the S-OMPS molecule, while the Ag@OMPS arrangement appears with a λmax at 300 nm. Conclusions: The green synthesis of AgNPs with OMP and OMPS has been investigated for their antibacterial properties. The nanoparticles were characterized using various techniques. The results indicate that the size of OMP nanoparticles is less than 40 nm, while the length of OMPS nanoparticles is less than 60 nm. Omeprazole@AgNPs and Ag@OMPS have demonstrated antibacterial properties, with the UV-Vis spectrum showing distinct peaks for the different arrangements. Overall, the study demonstrates the potential of utilizing AgNPs in combination with OMP and OMPS for enhanced antibacterial activities.