Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring
| Author | Davood Abbarin | en |
| Author | Abbas Ali Vafaei | en |
| Author | Ali Rashidy Pour | en |
| Author | Ahmad Reza Bandegi | en |
| Author | Abbasali Taherian | en |
| Author | Mehrnoosh Rahmani | en |
| Author | Morteza Jarrahi | en |
| Author | Katayoun Sedaghat | en |
| Orcid | Abbas Ali Vafaei [0000-0003-1178-3787] | en |
| Orcid | Ali Rashidy Pour [0000-0001-5006-1408] | en |
| Orcid | Ahmad Reza Bandegi [0000-0003-1834-0583] | en |
| Orcid | Katayoun Sedaghat [0000-0001-5424-8640] | en |
| Issued Date | 2023-04-30 | en |
| Abstract | Background: Autism spectrum is a type of developmental-neurodegenerative disease commonly reflected in social communications and associated with oxidative stress in the brain. Vitamins D and E, as strong antioxidants, may improve autistic-like behavioral disorders. Objectives: The aim of this study was to determine the effects of vitamins D and E on pain, threshold, motor coordination, and anxiety behavior, as well as oxidative stress parameters in an autistic model in rats. Methods: We induced an experimental model of congenital autism in the rat by injection of valproic acid (500 mg/kg) into pregnant rats on the day 12.5th of gestation. From postnatal day 30 to 60, male offspring received daily injections of vitamins D (5 µg/kg) and/or E (10 mg/kg) or vehicle. Next, their anxiety levels were assessed with the elevated plus maze and open field, pain thresholds with hot plate, motor and balance with rotarod, and spatial learning and memory with T-maze. The rat brain was then removed to measure oxidative markers, including Malondialdehyde, Glutathione, and Catalase. Results: Results indicated that injection of valproic acid-induced autistic-like behaviors, including increased pain threshold, increased anxiety, decreased exploring behaviors, reduced balance power, and motor learning, and produced oxidative stress. Administration of vitamins D and E significantly ameliorated these symptoms. Conclusions: These findings may indicate that vitamins D and E improved sensory, motor, anxiety, and cognitive deficits in an experimental model of autism, probably by reducing the oxidative stress and inflammatory process or maintaining balance in the neurotransmitter system. | en |
| DOI | https://doi.org/10.5812/mejrh-129627 | en |
| Keyword | Autism | en |
| Keyword | Vitamins D and E | en |
| Keyword | Valproic Acid | en |
| Keyword | Oxidative Stress | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring | en |
| Type | Research Article | en |