Spasmolytic Effect of Vitis Vinifera Leaf Hydroalcoholic Extract on Rat's Isolated Vas Deferens

Abstract

Introduction: Many reports have shown that the grape (Vitis vinifera) seed extract induces antioxidant, hypotensive hypolipidemic, and vasodilatory effects. We have recently shown the relaxatory effect of grape leaf extract on rat's aorta, ileum, uterus and frog's heart rate and contractility. The objective of this study was to investigate the spasmolytic effect of Vitis Vinifera Leaf Hydroalcoholic extract (VLHE) on rat's isolated vas deferens.