Oral Zinc Supplementation in Chronically HEV-Infected Patients Not Responding to Ribavirin Monotherapy
| Author | Thomas Horvatits | en |
| Author | Patrick Behrendt | en |
| Author | Niels Schuebel | en |
| Author | Martina Guthoff | en |
| Author | Johannes Wiegand | en |
| Author | Anna Harth | en |
| Author | Julia Mersi | en |
| Author | Marc Luetgehetmann | en |
| Author | Clemence Gallon | en |
| Author | Meike Rybczynski | en |
| Author | Zhaochao Liang | en |
| Author | Benjamin Maasoumy | en |
| Author | Vincent Mallet | en |
| Author | Lin Wang | en |
| Author | Sven Pischke | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Chronic hepatitis E virus (HEV) infection may progress to end-stage liver disease in immunosuppressed individuals. Ribavirin therapy is efficient in most chronic HEV patients, but 10% remain without a sustained virological response (SVR). Objectives: We aimed to study whether zinc supplementation could represent a therapeutic approach in these patients. Methods: Antiviral properties of zinc salts were studied in vitro (subgenomic-replicon system), in vivo (rabbit model), and retrospectively in patients with chronic hepatitis E who did not achieve SVR under ribavirin monotherapy. Results: Zinc inhibited HEV genotype 3 replication in vitro. In a model of acute HEV infection in immunocompetent rabbits, zinc + ribavirin did not improve viral clearance compared to ribavirin monotherapy. In chronically HEV-infected patients not responding to ribavirin (n = 12), viral clearance was observed in 4/12 (33%) patients receiving additional zinc supplementation. Conclusions: Oral zinc, an inexpensive, harmless dietary supplement, could potentially represent a rescue treatment option for a few patients with chronic hepatitis E without SVR under ribavirin monotherapy. Further studies are needed to elucidate the role of zinc in HEV. | en |
| DOI | https://doi.org/10.5812/hepatmon-130865 | en |
| Keyword | Hepatitis E | en |
| Keyword | HEV | en |
| Keyword | Antiviral | en |
| Keyword | Zinc | en |
| Publisher | Brieflands | en |
| Title | Oral Zinc Supplementation in Chronically HEV-Infected Patients Not Responding to Ribavirin Monotherapy | en |
| Type | Research Article | en |
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