Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?
| Author | Maryam Kazemi Aghdam | en |
| Author | Seyed Alireza Nadji | en |
| Author | Maliheh Khoddami | en |
| Author | Mohamad Mahdi Tehrani | en |
| Orcid | Maryam Kazemi Aghdam [0000-0001-9948-417X] | en |
| Issued Date | 2020-10-05 | en |
| Abstract | Background: Identifying etiologic factors contributing to Wilms tumor (WT) is necessary for its prevention and treatment. Oncogenic viruses cause nearly 20% of all human cancers. Although trials on preventing virus-caused cancers are complex and difficult, but they are not impossible to conduct. Human Cytomegalovirus (HCMV) and human herpes virus-6 (HHV6) can cause different types of cancers. Objectives: The current study aimed to investigate whether HCMV and HHV6-DNA are present in patients with WT. This is the first study of this kind in Iran. Methods: This study was performed on patients with kidney disorders who were referring to Mofid Pediatrics Hospital, Tehran (Iran), during 2010-16. In total, 98 kidney samples (49 patients with WT and 49 normal kidneys (autopsy) and kidneys with benign noninfectious lesions) were investigated to identify HCMV and HHV6-DNA. Qualitative Polymerase Chain reaction (PCR) method and nested polymerase chain reaction (nested-PCR) technique were used to identify HCMV and HHV6, respectively. Results: No significant difference was found between WT patients and controls concerning the HCMV or HHV6. Conclusions: Based on the findings, it can be concluded that there is no association between these viruses and WT. | en |
| DOI | https://doi.org/10.5812/pedinfect.103904 | en |
| Keyword | <i>Human Cytomegalovirus</i> | en |
| Keyword | <i>Human Herpes Virus-6</i> | en |
| Keyword | Polymerase Chain Reaction | en |
| Keyword | Wilms Tumor | en |
| Publisher | Brieflands | en |
| Title | Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link? | en |
| Type | Research Article | en |
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