Clinical Characteristics, Laboratory Features, and Outcomes of 151 Pediatric Patients with COVID-19 and MIS-C: A Single-center Study in the Northwest of Iran
| Author | Mahmoud Samadi | en |
| Author | Mahboobeh Azadi | en |
| Author | Amir Saeed | en |
| Author | Akbar Molaei | en |
| Author | Shahram Abdoli Oskouie | en |
| Author | Shamsi Ghaffari | en |
| Author | Ahmad Jamei Khosroshahi | en |
| Author | Sara Kaveh | en |
| Orcid | Mahmoud Samadi [0000-0003-2319-2300] | en |
| Orcid | Mahboobeh Azadi [0000-0002-0793-8531] | en |
| Orcid | Amir Saeed [0000-0001-9864-3087] | en |
| Orcid | Akbar Molaei [0000-0002-3264-9280] | en |
| Orcid | Shahram Abdoli Oskouie [0000-0001-5897-7883] | en |
| Orcid | Shamsi Ghaffari [0000-0002-1041-7139] | en |
| Orcid | Ahmad Jamei Khosroshahi [0000-0001-7186-2423] | en |
| Orcid | Sara Kaveh [0000-0002-6145-6314] | en |
| Issued Date | 2023-05-07 | en |
| Abstract | Background: To date, multiple outbreaks of coronavirus disease 2019 (COVID-19) have been reported. Moreover, a wide spectrum of multiple organ involvements has been reported. Objectives: This study aimed to describe and compare the clinical characteristics, laboratory features, and outcomes of pediatric patients with COVID-19 and Multisystem Inflammatory Syndrome of Children (MIS-C). Methods: This cohort retrospective study was performed on patients under 18 years admitted with a diagnosis of COVID-19 and MIS-C in a pediatric referral center in the northwest of Iran from March 2020 to June 2021. This study included the data obtained from three time points, including on admission, 1 week, and 3 months after admission. Results: In this study, 151 patients with a mean age of 5.3 ± 4.1 years were enrolled, out of whom 51.7% and 48.3% were in COVID-19 and MIS-C groups, respectively. Fever was observed in 64.9% of the patients. In the third-month follow-up, there was no abnormality in the neurologic, respiratory, or gastrointestinal systems. For most patients with cardiovascular involvement, normal ventricular and valvar function, and coronary arteries were obtained in follow-up. Approximately one-third of the subjects were admitted to the pediatric intensive care unit (PICU). Neonates, those with cardiac involvement and underlying disease, were at a higher risk for PICU admission (P < 0.001). Moreover, six patients died. Conclusions: Although irreversible post-COVID-19 organ involvement is uncommon among pediatric patients, routine and preplanned follow-up programs play an important role in achieving satisfactory outcomes. | en |
| DOI | https://doi.org/10.5812/pedinfect-132819 | en |
| Keyword | Intensive Care Unit | en |
| Keyword | Pediatric | en |
| Keyword | COVID-19 | en |
| Keyword | Pediatric Multisystem Inflammatory Disease | en |
| Keyword | COVID-19-related | en |
| Keyword | Follow-up Studies | en |
| Keyword | Child | en |
| Publisher | Brieflands | en |
| Title | Clinical Characteristics, Laboratory Features, and Outcomes of 151 Pediatric Patients with COVID-19 and MIS-C: A Single-center Study in the Northwest of Iran | en |
| Type | Research Article | en |
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