Serum Concentration of Selenium and GPX Enzyme Activity in Iranian Children with Asthma
| Author | Azardokht Tabatabaei | en |
| Author | Mohammad Babaee | en |
| Author | Nariman Moradi | en |
| Author | Mohammad Nabavi | en |
| Author | Saba Arshi | en |
| Author | Soudabeh Fallah | en |
| Orcid | Azardokht Tabatabaei [0000-0002-4643-7959] | en |
| Orcid | Mohammad Babaee [0000-0001-5171-8694] | en |
| Orcid | Nariman Moradi [0000-0001-7760-4804] | en |
| Orcid | Mohammad Nabavi [0000-0001-6558-0390] | en |
| Orcid | Saba Arshi [0000-0002-7277-3243] | en |
| Orcid | Soudabeh Fallah [0000-0002-7377-6577] | en |
| Issued Date | 2020-04-30 | en |
| Abstract | Background: Asthma is a disease with chronic airway inflammation, whereby the airway hyper-reactivity increases. Oxidative stress balance plays a critical role in asthma. Objectives: The present study aimed to evaluate serum glutathione peroxidase (GPX) enzyme activity and selenium levels in patients with asthma. Methods: This case-control study was conducted on 64 children aged 1 - 5 years, 32 subjects as controls, and 32 subjects with asthma who were selected randomly. The serum GPX activity and selenium levels of the studied subjects were determined spectrophotometrically. Results: The present study showed that serum GPX activity and Selenium (Se) levels of patients with asthma were significantly lower than those of controls (P < 0.001, P < 0.05, respectively). Conclusions: Reduction of serum GPX activity and Se concentration in patients could have a potential role in the pathogenesis and modulation of asthma. Micronutrient supplementation of Se may be beneficial in asthma. | en |
| DOI | https://doi.org/10.5812/modernc102396 | en |
| Keyword | Glutathione Peroxidase | en |
| Keyword | Selenium | en |
| Keyword | IgG | en |
| Keyword | Oxidative Stress | en |
| Keyword | Asthma | en |
| Publisher | Brieflands | en |
| Title | Serum Concentration of Selenium and GPX Enzyme Activity in Iranian Children with Asthma | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- mcj-17-2-102396.pdf
- Size:
- 433.34 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF