In vitro anti-bacterial effect of nano-polyamidoamine-G5 dendrimer
| Author | Soudabeh Alizadeh Matboo | en |
| Author | Shahram Nazari | en |
| Author | Leila Mohammadi | en |
| Author | Susan Bagheri | en |
| Author | Fakhraddin Akbari Dourbash | en |
| Author | Ahmadreza Yari | en |
| Author | Seyyed Ahmad Mokhtari | en |
| Author | A. li Niapour | en |
| Author | Seyyed Mohsen Mohseni | en |
| Issued Date | 2019-03-31 | en |
| Abstract | Introduction: Progress in nanotechnology in the past decayed has created various opportunities for evaluation of biological effects such as anti-bacterial effects of nanoparticles. This study was aimed to examine synthesis and the antibacterial effect of Nano-Polyamidoamine-G5 (NPAMAM-G5) dendrimer on Klebsiella Pneumoniae, Pseudomonas Aeruginosa, Shigella Dysenteriae and Bacillus Subtilis. Materials and Methods: NPAMAM-G5 dendrimers was synthesized by Tomalia’s divergent growth approach. The antibacterial effects of NPAMAM-G5 dendrimer were studied by disc diffusion and micro-dilution method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against gram-positive and gram-negative bacteria were determined according to Clinical and Laboratory Standards Institute (CLSI) guideline. Transmission electron microscopy (TEM) was used to analyze morphology and size of NPAMAM-G5. Results: Zone of inhibition in concentration 25μg/ml of NPAMAM-G5 dendrimers for Klebsiella Pneumoniae, Pseudomonas Aeruginosa, Shigella Dysenteriae and Bacillus Subtilis were 27, 13, 30 and 18 mm, respectively. There was a significant difference regarding the zone of inhibition between gram-negative and gram-positive bacteria (p | en |
| DOI | https://doi.org/ | en |
| Keyword | Gram Positive Bacteria | en |
| Keyword | Gram Negative Bacteria | en |
| Keyword | Dendrimers | en |
| Keyword | Polyamines | en |
| Keyword | Microbial Sensitivity Tests | en |
| Keyword | باکتریهای گرم منفی | en |
| Keyword | باکتریهای گرم مثبت | en |
| Keyword | نانودندریمر | en |
| Keyword | پلیآمینها | en |
| Keyword | آزمونهای حساسیت میکروبی | en |
| Publisher | Brieflands | en |
| Title | In vitro anti-bacterial effect of nano-polyamidoamine-G5 dendrimer | en |
| Type | Research Article | en |