Attenuation of Cisplathin-Induced Toxic Oxidative Stress by Propofol
| Author | Ghazaleh Taheri Moghadam | en |
| Author | Seyed-Mostafa Hosseini-Zijoud | en |
| Author | Tavakol Heidary Shayesteh | en |
| Author | Hassan Ghasemi | en |
| Author | Akram Ranjbar | en |
| Issued Date | 2014-10-01 | en |
| Abstract | Background: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-induced oxidative stress in rat. Objectives: In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both. Materials and Methods: Group one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress markers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant capacity (TAC) were measured. Results: Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered cisplatin -induced changes in TAC, TTG and LPO in blood. Conclusions: It is concluded that oxidative damage is the mechanism of cisplatin toxicity, which can be recovered by propofol. | en |
| DOI | https://doi.org/10.5812/aapm.14221 | en |
| Keyword | Propofol | en |
| Keyword | Cisplatin | en |
| Keyword | Oxibdative stress | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Attenuation of Cisplathin-Induced Toxic Oxidative Stress by Propofol | en |
| Type | Research Article | en |
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