Mineral and Bone Disease in Black African Hemodialysis Patients: A Report From Senegal
| Author | Sidy Seck | en |
| Author | Mohamed Dahaba | en |
| Author | Elhadj Ka | en |
| Author | Mouhamadou Cisse | en |
| Author | Seigne Gueye | en |
| Author | Ahmet Lemrabott Tal | en |
| Issued Date | 2012-09-01 | en |
| Abstract | Background: Chronic kidney disease related mineral and bone disease (CKD-MBD) is a worldwide challenge in hemodialysis patients. In Senegal, number of dialysis patients is growing but few data are available about their bone disorders. Objectives: To describe patterns of CKD-MBD in Senegalese dialysis patients. Patients and Methods: We performed a cross-sectional study including patients from three dialysis centres in Senegal. Diagnosis of different types of CKD-MBD relied on clinical, biological and radiological data collected from medical records in dialysis. Results: We included 118 patients and 79 of them presented CKD-BMD (prevalence of was 66.9 %). Mean age of CKD-MBD patients was 47.8 ± 15.7 years (16-81 years) and sex-ratio (Male/Female) was 1.15. Secondary hyperparathyroidism was the most frequent disorder (57 patients) followed by adynamic bone disease (21 patients) and osteomalacia (1 patients). The main clinical manifestations were bone pain (17.5% of cases), pruritus (36.8% of cases) and pathological fractures (2.5% of cases). Bone biopsy was not available. Valvular and peripheral vascular calcification were present in 24.5% and 21.2% of patients respectively. Management of CKD-MBD included optimization of dialysis, calcium bicarbonate, sevelamer, vitamin D analogues and calcimimetics. The NKF/DOQI recommended levels of serum calcium, phosphate and parathormone PTH were not achieved in one third of patients. Six patients presented major cardiovascular events during their dialysis period. Conclusions: CKD-MBD are frequent in Senegalese hemodialysis patients and they are dominated by high turn-over disease. Clinical and biological manifestations are unspecific and accurate diagnoses are often difficult in absence of histomorphometry. Treatment is suboptimal for many patients in a context of limited resources. | en |
| DOI | https://doi.org/10.5812/numonthly.4225 | en |
| URI | https://brieflands.com/journals/num/articles/16999 | en |
| Keyword | Renal Osteodystrophy | en |
| Keyword | Hemodialysis | en |
| Keyword | Senegal | en |
| Publisher | Brieflands | en |
| Title | Mineral and Bone Disease in Black African Hemodialysis Patients: A Report From Senegal | en |
| Type | Research Article | en |
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