Disseminated Bacille Calmette-Guérin Infection in Immunodeficient Infants: Report of Two Cases
| Author | Ahmed Ben Hadj Hassine |
| Author | Manel Marzouk |
| Author | Hichem Bargui |
| Author | Miniar Tfifha |
| Author | Mohamed Dhaou |
| Author | Jalel Boukadida |
| Issued Date | 2017-04-30 |
| Abstract | Introduction: The Bacille Calmette-Guérin (BCG), a live attenuated Mycobacterium bovis vaccine, is administered to all the newborns in Tunisia in order to prevent Tuberculosis (TB). Complications of this vaccine are uncommon. However, it poses a risk for children with unknown immunodeficiency. Case Presentation: We report on disseminated BCG disease in two infants, respectively, with severe combined immunodeficiency and human immunodeficiency virus (HIV). Evolution was fatal for both, despite adequate anti-tuberculosis treatment. Conclusions: Molecular methods are available to respond to the urgent need for rapid and specific diagnosis of local/regional or systemic BCG disease, using available commercial kits GenoType® MTBC and GenoType® MTBDRplus. These tests allow prevention of inoculation of live vaccines such as BCG among the next siblings until appropriate screening tests exclude primary or secondary immunodeficiency syndromes. |
| DOI | https://doi.org/10.5812/pedinfect.37490 |
| Keyword | Bacille Calmette-Guérin Vaccine |
| Keyword | Mycobacterium bovis |
| Keyword | Molecular Diagnostic Techniques |
| Keyword | Immunologic Deficiency Syndromes |
| Publisher | Brieflands |
| Title | Disseminated Bacille Calmette-Guérin Infection in Immunodeficient Infants: Report of Two Cases |
| Type | Case Report |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- apid-05-02-37490.pdf
- Size:
- 459.07 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF