Role of <i>Arctium lappa</i> L. Root (Burdock) Extract in CFA-induced Arthritis Rat Model: Impact on Antioxidant Activity and Inflammation
| Author | Mohammad Hosein Farzaei | en |
| Author | Arezoo Moini Jazani | en |
| Author | Mina Salimi | en |
| Author | Sahar Shafiei | en |
| Author | Hosna Khazaei | en |
| Author | Mohammad Hashemnia | en |
| Author | Mohammad Mehdi Gravandi | en |
| Author | Ramin Nasimi Doost Azgomi | en |
| Orcid | Mohammad Hosein Farzaei [0000-0001-7081-6521] | en |
| Orcid | Arezoo Moini Jazani [0000-0001-5004-1941] | en |
| Orcid | Mina Salimi [0000-0001-9419-1490] | en |
| Orcid | Sahar Shafiei [0009-0009-5528-1181] | en |
| Orcid | Hosna Khazaei [0000-0002-1058-7613] | en |
| Orcid | Mohammad Hashemnia [0000-0002-2899-4794] | en |
| Orcid | Mohammad Mehdi Gravandi [0000-0002-7995-5285] | en |
| Orcid | Ramin Nasimi Doost Azgomi [0000-0002-3836-3240] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Arctium lappa L. is a well-known medicinal herb recognized for its anti-inflammatory and antioxidant properties, which have been shown to be beneficial in the treatment of various diseases. Objectives: The present study aimed to explore the protective effects of the hydroalcoholic extract of A. lappa root in complete Freund’s adjuvant (CFA)-induced arthritis in rats. Methods: Arthritis was induced in Sprague-Dawley rats through a single subcutaneous CFA injection into the right hind paws. After induction, the animals were orally administered A. lappa at doses of 200 and 400 mg/kg, or prednisolone (as a reference drug), for a duration of 30 days. Blood and ankle joint samples were collected for analysis. The anti-arthritic effects were assessed through nociceptive behavioral tests, paw edema, body weight measurements, serum concentrations of tumor necrosis factor-α (TNF-α), nitric oxide (NO), glutathione (GSH), superoxide dismutase (SOD) activity, and histopathological evaluations. Results: The A. lappa root extract significantly improved body weight and reduced thermal hyperalgesia, as well as decreased paw edema in a dose-dependent manner (P < 0.001). Furthermore, A. lappa reduced inflammatory cytokines and increased antioxidant defenses in the serum of all treated rats (P < 0.05 to P < 0.001). Histologically, A. lappa notably restored the ankle joint architecture compared to untreated arthritic rats (P < 0.05 to P < 0.001). Conclusions: The results suggest that A. lappa has significant anti-arthritic potential by reducing inflammatory cytokines and enhancing serum antioxidant levels, which supports its traditional use in the management of joint diseases. | en |
| DOI | https://doi.org/10.5812/ijpr-162189 | en |
| Keyword | <i>Arctium lappa</i> | en |
| Keyword | Rheumatoid Arthritis | en |
| Keyword | Oxidative Stress | en |
| Keyword | Inflammation | en |
| Keyword | Complete Freund's Adjuvant (CFA) | en |
| Publisher | Brieflands | en |
| Title | Role of <i>Arctium lappa</i> L. Root (Burdock) Extract in CFA-induced Arthritis Rat Model: Impact on Antioxidant Activity and Inflammation | en |
| Type | Research Article | en |