Quantitative age related changess in the nucleus raphe dorsalis of the rat

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AuthorMohammadHosan TabriziAmjaden
Issued Date2000-09-30en
AbstractIntroduction. About 50% of serotonergic neurons of the CN.s exist in th e dorsal ra phe nucle us. To cha nge the seroto nin's ra te of C N.S indu ces man y disorde rs. Due to age increase. morphologic cha nges in number and diamet er of den drit es. numbe r of their spines, numbe r of fibers a nd ce llula r endings in the nucleus raphe dorsa lis a nd rate of their sta ining are observed. T he aim of thi s research is to survey of a ny cha nges in ne uron s numbers a nd volume of nucleus ra ph e dorsalis in ag ing. Materials and Methods. In this research 15 fe ma le a lbino rats with age of 3 days. 2 and 12 months were used. T he brain of these rats fixed by pe rfusio n method with BOEI N solution, th en the spe cimens st ain ed by Cluve r and Barrera me thod. The number of ce lls and volume of the nucle us raphe dorsa lis have been calculate d hy using eye pe ace micros cope. T he dat a were a na lysed by Kraskul-Wallis test and P < 0.05 was conside re d as significa nt. Results. Micros copic exa mina tio ns have heen show n that with incr easi ng age the number of neurons of the nucleus ra phe dorsalis and the volume of them significa ntly dec reased (P< 0.05). Conclusion. T hese q uantitative changes in higher ages. make the negative effects in vita l ac tivity of the ne uro ns, which may indu ce many disorde rs.en
DOIhttps://doi.org/en
KeywordNucle us Raph e Dor sal is: Reticular Formation, Seroton ergic System, Age Relat ed Cha ngesen
Keywordهسته رافه دورسال، تشکیلات مشبک، سیستم سروتونرژیک، تغییرات مرتبط با سنen
PublisherBrieflandsen
TitleQuantitative age related changess in the nucleus raphe dorsalis of the raten
TypeResearch Articleen

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