The Relationship Between Serum Resistin Levels and Diabetic Nephropathy in Type 2 Diabetic Patients
| Author | Shahnaz Tofangchiha | en |
| Author | Shima Rahimi | en |
| Author | Iraj Mirzaii-Dizgah | en |
| Author | Mahdi Isazadeh | en |
| Author | Nasrin Mansournia | en |
| Author | Yaser Taghavi | en |
| Author | Atoosa Moetaghedi Larijani | en |
| Orcid | Shahnaz Tofangchiha [0000-0003-0823-4875] | en |
| Orcid | Shima Rahimi [0000-0001-9190-7553] | en |
| Orcid | Iraj Mirzaii-Dizgah [0000-0002-0050-4191] | en |
| Orcid | Mahdi Isazadeh [0000-0002-8543-2181] | en |
| Orcid | Nasrin Mansournia [0000-0003-0621-2250] | en |
| Orcid | Yaser Taghavi [0000-0002-5053-8402] | en |
| Orcid | Atoosa Moetaghedi Larijani [0000-0003-2045-4045] | en |
| Issued Date | 2020-12-31 | en |
| Abstract | Background: Resistin reduces tissue sensitivity to insulin and causes hyperglycemia. Diabetic nephropathy is also a metabolic disorder caused by chronic hyperglycemia that causes kidney dysfunction. Objectives: This study aimed to investigate the relationship between serum resistin and diabetic nephropathy in diabetic patients who referred to Imam Reza Hospital in 2018 - 2019. Methods: This case-control study recruited 30 diabetic patients with nephropathy, 29 non-nephropathy diabetic patients, and 30 healthy controls via convenience sampling. Serum and 24-hour urine samples were taken from each person. After the determination of the glomerular filtration rate, samples were tested in a laboratory. Also, data were analyzed by SPSS software version 23, and P < 0.05 was considered significant. Results: Mean serum resistin was significantly different between the groups (F = 3.600, P = 0.032). Tukey’s follow-up test showed that resistin was critically higher in the diabetic nephropathy group than in the control group and healthy controls. There was a weak inverse relationship between glomerular filtration rate and serum resistin level (r = -0.233, P = 0.031). Conclusions: Levels of resistin may rise in people with diabetes associated with nephropathy. It seems that Serum resistin can be used as a biomarker to assess the severity of diabetes mellitus. | en |
| DOI | https://doi.org/10.5812/amh.107878 | en |
| Keyword | Resistin | en |
| Keyword | Diabetic Nephropathy | en |
| Keyword | Diabetes Mellitus | en |
| Publisher | Brieflands | en |
| Title | The Relationship Between Serum Resistin Levels and Diabetic Nephropathy in Type 2 Diabetic Patients | en |
| Type | Research Article | en |
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