Association Between Serum Levels of Vitamin D and Biochemical Markers Among Hematopoietic Stem Cell Transplantation Candidates: A Cross-Sectional Study
| Author | Hoda Zahedi | en |
| Author | Reza Amiri Khosroshahi | en |
| Author | Omid Sadeghi | en |
| Author | Mahshid Mehdizadeh | en |
| Author | Sayeh Parkhideh | en |
| Author | Mohammad Hadizadeh | en |
| Author | Fatemeh Naeini | en |
| Author | Abbas Hajifathali | en |
| Author | Mahdi Shadnoush | en |
| Orcid | Hoda Zahedi [0000-0003-4431-7459] | en |
| Orcid | Mahshid Mehdizadeh [0000-0002-8937-5495] | en |
| Orcid | Mohammad Hadizadeh [0000-0001-8168-6750] | en |
| Orcid | Abbas Hajifathali [0000-0002-2711-9277] | en |
| Orcid | Mahdi Shadnoush [0000-0002-3716-0994] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: Although vitamin D has been known as an effective substance in bone homeostasis, recent studies indicated a number of other biological properties attributed to vitamin D. Patients, who are candidates for hematopoietic stem cell transplantation (HSCT), were shown to be at high risk of vitamin D deficiency. Objectives: This study aimed at exploring the association between serum levels of vitamin D and biochemical markers among HSCT candidates. Methods: Totally, 214 patients, aged 18 to 65 years, were recruited in the current cross-sectional study. Within 24 hours of admission to the Bone Marrow Transplant ward, baseline clinical and demographic characteristics of study participants, serum levels of vitamin D, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin, albumin, total protein, CRP-albumin ratio (CAR), and body mass index (BMI) were assessed. Participants were divided into 4 groups based on their serum vitamin D levels: Subjects with deficient, insufficient, sufficient, and optimal levels of vitamin D. Results: Across the 4 defined categories of serum vitamin D levels, there was no significant difference in terms of BMI, laboratory parameters, inflammatory factors, and biochemical markers. This lack of significant variation remained in both unadjusted and adjusted models. Conclusions: These observations indicate a lack of significant association between serum vitamin D levels and BMI, inflammatory factors, and biochemical markers in individuals undergoing evaluation for HSTC. | en |
| DOI | https://doi.org/10.5812/ijcm-144271 | en |
| Keyword | Vitamin D | en |
| Keyword | Patients with Malignancy | en |
| Keyword | HSCT | en |
| Keyword | Biochemical Markers | en |
| Keyword | Inflammation | en |
| Publisher | Brieflands | en |
| Title | Association Between Serum Levels of Vitamin D and Biochemical Markers Among Hematopoietic Stem Cell Transplantation Candidates: A Cross-Sectional Study | en |
| Type | Research Article | en |
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