Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats

Abstract

Background : Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects f ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.Materials and Methods : In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups (each group 7 rats). Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg (NV25), ordinary vanadate 25 mg/kg (V25), nonovanadate 15 mg/kg (NV15) and water ordinary vanadate 25 mg/kg (WV25) groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride (TG), total cholesterol (TC), HDL-c and LDL-c were measured at both time and compared between groups.Results : All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group (p