Effects of Aerobic Interval Training Along with <i>Ginkgo biloba</i> Supplementation on Passive Avoidance Memory and GDNF Gene Expression in Alzheimer Rats
| Author | Sepideh Basirat Dehkordi | en |
| Author | Mehdi Mogharnasi | en |
| Author | Majid Vahidian-Rezazadeh | en |
| Author | Mohsen Saravani | en |
| Orcid | Sepideh Basirat Dehkordi [0000-0001-9064-056X] | en |
| Orcid | Mehdi Mogharnasi [0000-0002-9351-5948] | en |
| Orcid | Majid Vahidian-Rezazadeh [0000-0001-7280-4188] | en |
| Orcid | Mohsen Saravani [0000-0001-8492-673X] | en |
| Issued Date | 2024-05-31 | en |
| Abstract | Background: Alzheimer's disease (AD) represents the most prevalent form of dementia, characterized by memory loss, and is a complex, progressive neurodegenerative condition. Objectives: This study aimed to explore the impact of aerobic interval training (AIT) combined with Ginkgo biloba (GB) supplementation on passive avoidance memory function and the expression of the glial cell-derived neurotrophic factor (GDNF) gene in rats afflicted with AD. Methods: A total of forty-four male Wistar rats, each weighing approximately 250 ± 20 g, were maintained in a controlled environment at a specified temperature. Over 8 weeks (5 days per week), they underwent AIT and received GB supplements at a dosage of 100 mg/kg. The rats were randomly assigned into six groups: Healthy control (HC) with 7 rats, AD control (AC) with 8 rats, amyloid-β (Aβ) injection plus GB supplement (Aβ + GB) with 8 rats, Aβ injection plus GB supplement plus AIT (Aβ + GB + AIT) with 8 rats, Aβ injection plus AIT (Aβ + AIT) with 8 rats, and sham surgery (SS) with 5 rats. The shuttlebox apparatus was utilized to assess the effect of Aβ on passive avoidance memory and to confirm disease induction. GDNF gene expression was measured using the qRT-PCR method. Results: The study found significant improvements in passive avoidance memory in the Aβ + AIT and Aβ + GB + AIT groups compared to the AC group after 8 weeks of AIT and GB supplementation (P = 0.02 and P = 0.000, respectively). Long-term memory performance was notably enhanced in the Aβ + GB + AIT group (P = 0.000). Additionally, GDNF expression significantly increased in the Aβ + GB + AIT and Aβ + GB groups in comparison to the AC group (P = 0.000 and P = 0.01, respectively). Conclusions: A synergistic effect of AIT and GB supplementation was observed, leading to an increase in GDNF gene expression and improvements in both passive avoidance memory and long-term memory in male rats with AD. | en |
| DOI | https://doi.org/10.5812/jjnpp-144050 | en |
| Keyword | Aerobic Interval Training | en |
| Keyword | <i>Ginkgo biloba</i> | en |
| Keyword | Passive Avoidance Memory | en |
| Keyword | GDNF | en |
| Keyword | Alzheimer’s Disease, Rats | en |
| Publisher | Brieflands | en |
| Title | Effects of Aerobic Interval Training Along with <i>Ginkgo biloba</i> Supplementation on Passive Avoidance Memory and GDNF Gene Expression in Alzheimer Rats | en |
| Type | Research Article | en |
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