Association of Clinical Insomnia with Cognitive Impairment, Pain, Psychiatric Comorbidity, and Clinical Characteristics in Patients with Seizure Disorders: An Analytical Cross-Sectional Study
| Author | Ghasem Salehpour | en |
| Author | Changiz Rahimi | en |
| Author | Nurallah Mohammadi | en |
| Orcid | Ghasem Salehpour [0000-0001-6886-2174] | en |
| Orcid | Changiz Rahimi [0000-0002-7180-364X] | en |
| Orcid | Nurallah Mohammadi [0000-0002-0413-2743] | en |
| Issued Date | 2026-10-31 | en |
| Abstract | Background: Insomnia is a common complaint among patients with seizure disorders and has a complex relationship with the condition. The coexistence of insomnia and seizures may lead to cognitive impairment, a higher likelihood of psychiatric disorders, increased pain perception, and more severe disease. Objectives: This study aimed to examine the associations between clinical insomnia and cognitive function, psychiatric disorders, pain quality and intensity, and clinical features in patients with seizure disorders. Methods: In this analytical cross-sectional study, 68 patients with seizure disorders were recruited through consecutive sampling and divided into two groups: those with clinical insomnia and those without. Demographic and clinical data were collected, and assessments included the Insomnia Severity Index (ISI), Montreal Cognitive Assessment (MoCA), Structured Clinical Interview for DSM-5 Disorders–Clinician Version (SCID-5-CV), McGill Pain Questionnaire (MPQ), Visual Analog Scale (VAS), and body mass index (BMI). Data were analyzed using independent-samples t tests, multivariate and univariate analyses of covariance, chi-square tests, Fisher’s exact test, and the Mann–Whitney U test. Results: After adjustment for age, significant differences were observed between patients with seizure disorders with and without clinical insomnia in abstraction, orientation, total MoCA scores, and pain-related outcomes (P < 0.05). In addition, patients with insomnia had a higher frequency of both current and past major depressive disorder (MDD) episodes, current manic episodes, and generalized anxiety disorder (GAD), as well as significantly more severe indicators of clinical disease (P < 0.05). Conclusions: Clinical insomnia was associated with poorer cognitive functioning, greater psychiatric comorbidity, a greater pain burden, and less favorable clinical characteristics among patients with seizure disorders. | en |
| DOI | https://doi.org/10.5812/zjrms-169726 | en |
| URI | https://brieflands.com/journals/zjrms/articles/169726 | en |
| Keyword | Insomnia | en |
| Keyword | Seizures | en |
| Keyword | Psychiatric Disorders | en |
| Keyword | Pain | en |
| Keyword | Cognitive Impairment | en |
| Publisher | Brieflands | en |
| Title | Association of Clinical Insomnia with Cognitive Impairment, Pain, Psychiatric Comorbidity, and Clinical Characteristics in Patients with Seizure Disorders: An Analytical Cross-Sectional Study | en |
| Type | Research Article | en |
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