Fibrin Nanoparticles as a Promising Anti-cancer Activity on MCF-7 Cells
| Author | Nahid Moradi Gharibvand | en |
| Author | Batool Hashemi Beni | en |
| Orcid | Batool Hashemi Beni [0000-0001-9656-2355] | en |
| Issued Date | 2024-01-31 | en |
| Abstract | Background: Drug delivery methods based on nanoparticles have shown promise in the treatment of cancer. The nanoparticles (NPs) have a cytotoxicity effect on cancer cells. Objectives: This study aimed to evaluate the effect of fibrin nanoparticles (FNPs) on breast cancer cells. Methods: MCF-7 cell lines were treated with 100 µg/mL of FNP for 5 days. On day five, gene and protein expression were evaluated to determine the anti-cancer effects of the FNPs. Results: BCL2, an anti-apoptotic (BCL2) and angiogenic (VEGF) genes and proteins were downregulated in the FNP treatment in comparison with control cells. Conclusions: The study's findings indicate that FNPs considerably reduce anti-apoptotic and angiogenic gene expression in human breast cancer cells. | en |
| DOI | https://doi.org/10.5812/chbs-154439 | en |
| Keyword | Fibrin Nanoparticles | en |
| Keyword | MCF-7 | en |
| Keyword | Anti-activity | en |
| Publisher | Brieflands | en |
| Title | Fibrin Nanoparticles as a Promising Anti-cancer Activity on MCF-7 Cells | en |
| Type | Research Article | en |