The Prevalence of Antibiotic Resistance to Polymyxins in Clinical Isolates of <i>Acinetobacter baumannii</i> in Iran and the World: A Systematic Review and Meta-Analysis
| Author | Fatemeh Sayehmiri | en |
| Author | Mohammad Yousef Alikhani | en |
| Author | Kourosh Sayehmiri | en |
| Author | Manoochehr Karami | en |
| Author | Jalal Ghaderkhani | en |
| Orcid | Manoochehr Karami [0000-0002-9026-3757] | en |
| Issued Date | 2017-12-31 | en |
| Abstract | Background: Acinetobacter baumannii is one of the most important opportunistic pathogens responsible for several nosocomial infections. A major problem in treatment is antibiotic resistance. Methods: By searching international and national databases, including PubMed, Google Scholar, Web of Science, SID, Magiran, IranDoc and IranMedex, 38 articles between years 2002 to 2016 published world-wide were extracted and analyzed using the meta-analysis method and random effects model. The heterogeneity of studies was assessed using the I2 index. Data were analyzed with the R and STATA (Ver 11/2) software. Results: Forty-three articles were selected for this study. Drug-resistance of Acinetobacter baumannii towards Polymyxin was reported as 5%, yet for Colistin 4% was estimated. Resistance rates to Polymyxin and Colistin in the continent of America and Asia was 6% and Sensitivity rate to Polymyxin and Colistin was 96% and 80%, respectively. Conclusions: Given that drug resistance rate of Acinetobacter baumannii to Polymyxin and Colistin in this study was 5% and 4%, respectively, thus indicating high sensitivity of Acinetobacter baumannii to these antibiotics, this group can be administered as appropriate therapeutic agents against these bacteria. | en |
| DOI | https://doi.org/10.5812/semj.57580 | en |
| Keyword | Prevalence of Resistance | en |
| Keyword | Antibiotics | en |
| Keyword | Polymyxins | en |
| Keyword | Colistin | en |
| Keyword | <i>Acinetobacter baumannii</i> | en |
| Publisher | Brieflands | en |
| Title | The Prevalence of Antibiotic Resistance to Polymyxins in Clinical Isolates of <i>Acinetobacter baumannii</i> in Iran and the World: A Systematic Review and Meta-Analysis | en |
| Type | Review Article | en |
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