Possible Involvement of Hepatic Phosphatidate Phosphohydrolase in the Mechanisms of Actions of Certain Antilipemic Drugs in Rats
| Author | Bahram Haghighi | en |
| Author | Mani Kharazizadeh | en |
| Author | Mohammad Ali Attar | en |
| Issued Date | 2007-10-31 | en |
| Abstract | The effects of therapeutic doses of dillsun, garsin, antum and statins on rat liver cytosolic phosphatidate phosphohydrolase (PAP) activity, a key enzyme in triacylglycerol synthesis, and on serum and liver lipids were examined. Lovastatin and simvastatin both stimulated the enzyme activity by 29% and 43%, respectively. The stimulatory effects were dose-dependent and accompanied by the decline in triacylglycerol and cholesterol concentrations of serum (20-29%) and liver (12-29%) suggesting a possible feed-back mechanism for PAP control. Dillsun (0.5-2 ml/day) did not affect PAP activity and liver lipids but lowered serum triacylglycerol (27%) and cholesterol (20%) concentrations at a dose of 2 ml/day. Antum administration also showed similar pattern as dillsun except that it caused a decrease in the liver lipids as well. Garsin (250-1000 mg/Kg) inhibited PAP activity (14-22%) with simultanous decrease in the liver and serum lipids; maximum decrease in serum triacylglycerol and cholesterol were 14% and 21%, respectively. The data demonstrated that the antilipidemic drugs tested exert their effects, at least in part, through alteration of hepatic PAP activity. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.732 | en |
| Keyword | Garsin | en |
| Keyword | Antum | en |
| Keyword | Dillsun | en |
| Keyword | simvastatin | en |
| Keyword | Lovastatin | en |
| Keyword | Phosphatidate phosphohydrolase | en |
| Publisher | Brieflands | en |
| Title | Possible Involvement of Hepatic Phosphatidate Phosphohydrolase in the Mechanisms of Actions of Certain Antilipemic Drugs in Rats | en |
| Type | Research Article | en |
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