Candidemia in the Neonatal Intensive Care Unit: Insights on Epidemiology and Antifungal Drug Susceptibility Patterns
| Author | Dina M. Hassan | en |
| Author | Reham H. A. Yousef | en |
| Author | Walaa A. Abu Elhamed | en |
| Author | Aliaa A. Ali | en |
| Author | Lamiaa A. Madkour | en |
| Accessioned Date | 2023-06-21T13:26:20Z | |
| Available Date | 2023-06-21T13:26:20Z | |
| Issued Date | 2019-01-31 | en |
| Abstract | Background: Being the culprit in 9% - 13% of neonatal bloodstream infections (BSIs), candidemia has been escalating to worrisome levels in the past few decades. While C. albicans has traditionally been the most common isolate, non-albicans Candida spp. are currently gaining a foothold. Objectives: We endeavored to investigate the epidemiological features of neonatal candidemia with special emphasis on non-albicans candidemia. Hence, we evaluated the incidence, risk factors, antifungal susceptibility, and case fatality rate of candidemia patients in the NICU. Methods: Blood samples were collected from 1296 neonates admitted to the NICU of a tertiary care hospital. Then, only neonates with positive blood cultures were enrolled. Incidence and risk factors of albicans and non-albicans candidemia were evaluated. The E-test was employed to determine the minimum inhibitory concentrations of fluconazole, itraconazole, voriconazole, amphotericin B, and caspofungin. Results: Out of 214 neonates with BSI, candidemia afflicted 32 neonates (15%). The predominant isolate was C. tropicalis (43.8%), followed by C. albicans (25%). Both antibiotic use and antifungal prophylaxis were contributing factors (P values of 0.02 and < 0.01, respectively). Susceptibility testing revealed that 87.5% of the retrieved Candida isolates were sensitive to amphotericin B, 81.25% to fluconazole, 75% to voriconazole, and 62.5% to itraconazole while 48.75% were sensitive to caspofungin. Conclusions: Neonatal candidemia often carries an ominous prognosis. The worldwide progressive shift towards non-albicans candidemia necessitates regular surveillance and monitoring of laboratory data. An epidemiological knowledge is critical in terms of preemptive management that should encompass disciplined infection control practices and a restrictive policy for antibiotic and antifungal prophylaxis. | en |
| DOI | https://doi.org/10.5812/pedinfect.81090 | en |
| URI | https://repository.brieflands.com/handle/123456789/9628 | |
| Keyword | <i>Candidemia</i> | en |
| Keyword | <i>C. tropicalis</i> | en |
| Keyword | Neonates | en |
| Keyword | NICU | en |
| Keyword | Non-<i>albicans Candida</i> | en |
| Publisher | Brieflands | en |
| Title | Candidemia in the Neonatal Intensive Care Unit: Insights on Epidemiology and Antifungal Drug Susceptibility Patterns | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- apid-7-1-81090.pdf
- Size:
- 133.53 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF