Changing Epidemiology of Chronic Hepatitis C: A University Hospital Experience
| Author | Süheyla Kömür | en |
| Author | Behice Kurtaran | en |
| Author | Yusuf Kemal Arslan | en |
| Author | Ferit Kuscu | en |
| Author | Sezin Hoşgel Sevdimbaş | en |
| Author | Seza Ayse Inal | en |
| Author | Aslıhan Candevir | en |
| Author | Yesim Tasova | en |
| Orcid | Süheyla Kömür [0000-0003-2414-559X] | en |
| Orcid | Behice Kurtaran [0000-0002-2081-4664] | en |
| Orcid | Ferit Kuscu [0000-0001-5662-8305] | en |
| Orcid | Seza Ayse Inal [0000-0002-1182-7164] | en |
| Orcid | Aslıhan Candevir [0000-0001-9340-516X] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: Hepatitis C virus (HCV) infection remains a significant public health problem worldwide, with varying epidemiological trends over time necessitating continual surveillance and intervention strategies. Objectives: This retrospective study aimed to examine trends in demographics, transmission routes, and disease characteristics among 635 patients diagnosed with HCV infection between 2003 and 2023. Methods: Data on demographics, HCV RNA levels, liver enzymes, genotype distribution, and transmission routes were retrospectively analyzed. The study period was divided into four segments for detailed analysis. Results: There was a gradual increase in the diagnosed cases over the study period, particularly noticeable after 2012. The mean age at diagnosis remained stable from 2003 - 2007 to 2008 - 2012 but decreased significantly in the following years (P = 0.001). Male predominance was observed throughout the study, with a notable increase in the male/female ratio over time (P < 0.001). Intravenous drug use (IVDU) emerged as the predominant transmission route, reaching 68.3% in 2018 - 2022 (P < 0.001). The prevalence of incarceration history among patients increased significantly, reaching 24.6% in 2018 - 2022 (P < 0.001). Conclusions: This study highlights the dynamic changes in hepatitis C epidemiology over two decades in southern Turkey, highlighting the increasing burden in younger populations, the increasing prevalence of IVDU as a transmission route, and the changing genotype distribution. | en |
| DOI | https://doi.org/10.5812/hepatmon-148127 | en |
| Keyword | Hepatitis C | en |
| Keyword | Epidemiology | en |
| Keyword | Intravenous Drug Users | en |
| Keyword | Modes of Transmission | en |
| Publisher | Brieflands | en |
| Title | Changing Epidemiology of Chronic Hepatitis C: A University Hospital Experience | en |
| Type | Research Article | en |
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