Analysis of the Distribution, Drug Susceptibility and Drug Resistance of <i>Staphylococcus aureus</i> Infection in the Hainan Area of China
| Author | Liuying Deng | en |
| Author | Weichen Yan | en |
| Author | Jie Wu | en |
| Author | Xiaozheng Tang | en |
| Orcid | Liuying Deng [0009-0000-0934-5126] | en |
| Orcid | Weichen Yan [0009-0002-5953-1810] | en |
| Orcid | Jie Wu [0009-0000-3367-1992] | en |
| Orcid | Xiaozheng Tang [0009-0008-0411-4597] | en |
| Issued Date | 2025-11-30 | en |
| Abstract | Background: Staphylococcus aureus causes skin, respiratory, and bloodstream infections; methicillin-resistant Staphylococcus aureus (MRSA) presents major challenges due to multidrug resistance. Hainan’s high population mobility and uneven healthcare resources may influence the local epidemiology. This five-year inpatient dermatology study is warranted because skin and soft tissue infection (SSTI)-focused, locality-specific data for Hainan are scarce. It provides clinically actionable evidence by analyzing 1,515 isolates with year-over-year trends (including MRSA), directly informing empiric therapy and antimicrobial stewardship in this setting. Objectives: The present study aimed to investigate the distribution, susceptibility, and drug resistance of S. aureus in Hainan, China. Methods: We conducted a retrospective study of 1,515 dermatology inpatients with skin or soft tissue S. aureus infection (January 2019 - December 2023). We summarized the clinical characteristics and annual susceptibility profiles. Susceptibility interpretations followed Clinical and Laboratory Standards Institute (CLSI) M100 guidance (2019: Ed29; 2020: Ed30; 2021: Ed31; 2022: Ed32; 2023: Ed33). Results: Males comprised 58.90% - 69.54% annually. The lower limbs were the most commonly affected site (54.52% - 63.14%). Secretions predominated as specimens (1,396/1,515; 92.15%). Generalized eczema was common (39.95% - 47.46%). Staphylococcus aureus exhibited persistently high penicillin resistance (87.6% - 93.78%; susceptibility: 6.22% - 12.4%) but retained useful susceptibility to amikacin, nitrofurantoin, linezolid, tigecycline, teicoplanin, and vancomycin. From 2019 - 2023, MRSA susceptibility to key agents (linezolid, vancomycin, teicoplanin, and tigecycline) remained greater than 30%; the yearly patterns were stable. Conclusions: Among Hainan dermatology inpatients (2019 - 2023), S. aureus infections were predominantly in males and often involved the lower limbs and secretion specimens, with frequent generalized eczema. While penicillin resistance remains high, S. aureus — including MRSA — retains clinically meaningful susceptibility to several agents, supporting local empiric therapy and stewardship (largest regional cohort, n = 1,515). | en |
| DOI | https://doi.org/10.5812/jjm-165736 | en |
| Keyword | Hainan Region of China | en |
| Keyword | <i>Staphylococcus aureus</i> | en |
| Keyword | Infection Distribution | en |
| Keyword | Drug Sensitivity | en |
| Keyword | Changes in Drug Resistance | en |
| Publisher | Brieflands | en |
| Title | Analysis of the Distribution, Drug Susceptibility and Drug Resistance of <i>Staphylococcus aureus</i> Infection in the Hainan Area of China | en |
| Type | Research Article | en |
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