Invasive Fungal Infections Among Patients with Hematological Malignancies: A Two-Year Multicentric Study from Tehran, Iran
| Author | Davod Sheikh-Hoseini | en |
| Author | Saeed Soleiman-Meigooni | en |
| Author | Hassan Jalaeikhoo | en |
| Author | Jalil Rajabi | en |
| Author | Mohammad Hassan Kazemi-Galougahi | en |
| Author | Taher Azimi | en |
| Author | Ali Asgari | en |
| Orcid | Saeed Soleiman-Meigooni [0000-0001-5641-7380] | en |
| Orcid | Hassan Jalaeikhoo [0000-0001-6010-335X] | en |
| Orcid | Jalil Rajabi [0009-0007-9067-0735] | en |
| Orcid | Mohammad Hassan Kazemi-Galougahi [0000-0003-4601-6457] | en |
| Orcid | Taher Azimi [0000-0003-0213-5227] | en |
| Orcid | Ali Asgari [0000-0002-3047-0412] | en |
| Issued Date | 2024-04-30 | en |
| Abstract | Background: Invasive fungal infection (IFI) is a life-threatening condition, particularly in individuals with compromised immune systems. Objectives: Our study aims to evaluate IFI in hospitalized patients with hematological malignancies. Methods: In this retrospective cross-sectional study, we evaluated patients with hematological malignancies admitted to two university hospitals in Tehran, Iran, from 2020 to 2021 for IFI. We selected only those patients who had been hospitalized for at least four days for antimicrobial treatment. Data analysis was conducted using SPSS-26 software, employing Mann-Whitney U, chi-square, and Fisher exact tests. Results: During the study period, 60 out of 213 patients with hematological malignancies were admitted for antimicrobial treatment. The average age of the patients was 57.1 years, with fever being the most common symptom, reported in 63.3% of cases. We identified 24 cases of Conclusions: Our study revealed that severe neutropenia is a significant risk factor for IFI, and the mortality rate associated with IFI remains high despite advances in the treatment of hematological malignancies. | en |
| DOI | https://doi.org/10.5812/jjm-144500 | en |
| Keyword | Invasive Fungal Disease | en |
| Keyword | Hematological Malignancy | en |
| Keyword | Neutropenia | en |
| Keyword | <i>Aspergillus</i> | en |
| Keyword | <i>Candida</i> | en |
| Publisher | Brieflands | en |
| Title | Invasive Fungal Infections Among Patients with Hematological Malignancies: A Two-Year Multicentric Study from Tehran, Iran | en |
| Type | Research Article | en |