The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG
| Author | Kamal Fani | en |
| Author | mahdi shadnoush | en |
| Author | alireza jahangirifard | en |
| Author | Mahnoosh Foroughi | en |
| Author | Hossein Ali Jelveh Moghaddam | en |
| Author | Ali Dabbagh | en |
| Orcid | Kamal Fani [0000-0002-7921-257X] | en |
| Orcid | mahdi shadnoush [0000-0002-3716-0994] | en |
| Orcid | Mahnoosh Foroughi [0000-0002-5053-0793] | en |
| Orcid | Ali Dabbagh [0000-0003-4344-8131] | en |
| Issued Date | 2018-09-30 | en |
| Abstract | Introduction: a number of preventive or therapeutic strategies have been proposed to compensate for the inflammatory process during adult cardiac surgeries; none have been considered definitive. 1,25 (OH)2 Vitamin D3 is among the so called physiologic hormones with immunomodulatory effects. This study assessed the effect of oral Vitamin D on serum levels of IL-1, IL-6 and TNF-? in adult CABG.Materials and methods: in a double blind placebo controlled clinical trial, 80 patients entered the study after qualifying study criteria; being divided to Vitamin D and placebo groups, serum cytokines (IL-1, IL-6, and TNF-?) were measured preoperatively and also during the 1st day after the operation.Results: serum TNF-? levels were similar in the 2 groups; however, postoperative levels of IL-1 and IL-6 were significantly lower in Vitamin D group.Conclusion: the current study demonstrated that oral Vitamin D supplements could augment immunomodulatory effects in adult patients undergoing cardiac surgical procedures (mainly CABG).Keywords:?Vitamin D, Cardiopulmonary Bypass, Cytokine, Inflammation | en |
| DOI | https://doi.org/10.22037/jcma.v3i3.19258 | en |
| Keyword | 1 | en |
| Keyword | 25-Dihydroxyvitamin D3 | en |
| Keyword | cytokine | en |
| Keyword | coronary artery bypass graft | en |
| Keyword | inflammation | en |
| Keyword | en | |
| Publisher | Brieflands | en |
| Title | The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG | en |
| Type | Original Articles | en |
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