Morphine/Codeine Ratio, a Key in Investigating a Case of Doping
| Author | Tohid Seif-Barghi | en |
| Author | Navid Moghadam | en |
| Author | Farzad Kobarfard | en |
| Issued Date | 2015-12-01 | en |
| Abstract | Introduction: Consumption of codeine can lead to positive urine test for morphine in athletes. Morphine is classified as a prohibited doping drug while Codeine is not. Morphine/codeine ratio is used in forensic medicine to distinguish the consumption of codeine from abuse of morphine and other narcotics. Case Presentation: We present an athlete with positive urine test for morphine with a history of consumption of codeine. The disciplinary committee came to conclusion that the athlete had not consumed morphine and did not violate doping code based on morphine/codeine ratio. Conclusions: Analysis of codeine to morphine metabolism rate is needed when we are using morphine/codeine ratio to rule out abuse of narcotics. WADA should consider analysis for the CYP2D6 alleles (main metabolizer of codeine) in case of including morphine/codeine ratio in future prohibited list. The possibility of ultra-rapid CYP2D6 cannot be ruled out in certain results of morphine/codeine near the cut point. | en |
| DOI | https://doi.org/10.5812/asjsm.28798 | en |
| Keyword | Doping in Sports | en |
| Keyword | CYP2D6 | en |
| Keyword | Morphine | en |
| Keyword | Codeine | en |
| Publisher | Brieflands | en |
| Title | Morphine/Codeine Ratio, a Key in Investigating a Case of Doping | en |
| Type | Case Report | en |
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