Antidepressant Effect of Combined Ketamine and Electroconvulsive Therapy on Patients With Major Depressive Disorder: A Randomized Trial
| Author | Narges Shams Alizadeh | en |
| Author | Azad Maroufi | en |
| Author | Karim Nasseri | en |
| Author | Seyed Hosein Sadeghi Najafabadi | en |
| Author | Ali Mousavi Taghiabad | en |
| Author | Fardin Gharibi | en |
| Author | Gholam Reza Esfandiari | en |
| Orcid | Azad Maroufi [0000-0002-6971-0196] | en |
| Issued Date | 2015-09-28 | en |
| Abstract | Background:: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response. Objectives:: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT). Patients and Methods:: Twenty-two patients with MDD received Ketamine and Propofol as anesthetic agents compared with 20 patients as the control group who received Propofol in a double-blind randomized clinical trial. The Hamilton rating scale for depression was used to determine the changes in symptoms severity during ECT and a 2-week follow-up. Results:: Both groups showed a reduction in depression severity, but there was no significant difference between the groups in the recovery process (P = 0.92). However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042). Conclusions:: This study could not show the effect of Ketamine on depression recovery in a 2-week follow-up period. Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT. | en |
| DOI | https://doi.org/10.17795/ijpbs-1578 | en |
| Keyword | Antidepressants | en |
| Keyword | Electroconvulsive Therapy | en |
| Keyword | Ketamine | en |
| Publisher | Brieflands | en |
| Title | Antidepressant Effect of Combined Ketamine and Electroconvulsive Therapy on Patients With Major Depressive Disorder: A Randomized Trial | en |
| Type | Research Article | en |
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