Utilizing Immunoinformatics to Target Brain Tumors; An Aid to Current Neurosurgical Practice
| Author | Kiarash Saleki | en |
| Author | Payam Payandeh | en |
| Author | Mahdi Shakeri | en |
| Author | Ramtin Pourahmad | en |
| Author | Mohammad Banazadeh | en |
| Author | Parsa Alijanizadeh | en |
| Author | Mohamad Hosein Mohamadi | en |
| Author | Meisam Akhlaghdoust | en |
| Orcid | Kiarash Saleki [0000-0003-4159-7299] | en |
| Orcid | Meisam Akhlaghdoust [0000-0003-0484-9098] | en |
| Issued Date | 2022-12-31 | en |
| Abstract | Context: Despite major advancements in the field, the current neurosurgical practice requires an interdisciplinary approach. It is known that surgical practice and other cancer-eliminating treatments can be combined for optimal results. However, recent attempts have failed to address many debilitating conditions, indicating an emergent need for novel interdisciplinary therapeutic approaches. Evidence Acquisition: We searched PubMed and Google Scholar for the keywords “immunoinformatics,” “in silico,” “neurology,” and “neurosurgery.” Without time restriction. Results: The immune system is versatile because it is involved in physiological brain function and affects the course of central nervous system (CNS) disease and infection. A novel approach combines neurosurgery and immunoinformatics for optimal results. For instance, brain tumors, such as glioblastoma multiforme (GBM), are still associated with a severely reduced survival of patients, and resection of tumors may provide little help. In silico approaches could help to identify molecular pathways and design immunotherapies for such conditions at a significantly increased speed compared to traditional vaccinology approaches. Conclusions: The neurosurgical practice could be affected by different infectious organisms. These organisms can be targeted by in silico vaccinology techniques. Here, we provide a brief overview of bioinformatics/immunoinformatics and discuss the possible role of immunoinformatics in neurosurgery. In light of the current Coronavirus disease-2019 (COVID-19) epidemic, projections for future studies are also included. | en |
| DOI | https://doi.org/10.5812/ipmn-131144 | en |
| Keyword | Neuroimmunology | en |
| Keyword | <i>In silico</i> | en |
| Keyword | Vaccine | en |
| Keyword | Brain Tumors | en |
| Keyword | Neurosurgery | en |
| Keyword | Immunoinformatics. | en |
| Publisher | Brieflands | en |
| Title | Utilizing Immunoinformatics to Target Brain Tumors; An Aid to Current Neurosurgical Practice | en |
| Type | Review Article | en |
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