A Search for Mitochondrial Damage in Alzheimer’s Disease Using Isolated Rat Brain Mitochondria
| Author | Mehrdad Faizi | en |
| Author | Enayatollah Seydi | en |
| Author | Sadegh Abarghuyi | en |
| Author | Ahmad Salimi | en |
| Author | Sanaz Nasoohi | en |
| Author | Jalal Pourahmad | en |
| Issued Date | 2016-03-31 | en |
| Abstract | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (30ng, by stereotaxy) in each hemisphere of the Wistar rat brain. Then memory dysfunction, oxidative stress and apoptosis induced by Aβ peptide were investigated on isolated brain mitochondria obtained from infected rat. Our results showed memory impairment in rats after receiving an Aβ peptide. We also found significant rise (P | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1819 | en |
| Keyword | Alzheimer disease | en |
| Keyword | amyloid-β peptide | en |
| Keyword | Mitochondria | en |
| Keyword | Oxidative stress | en |
| Keyword | Apoptosis | en |
| Publisher | Brieflands | en |
| Title | A Search for Mitochondrial Damage in Alzheimer’s Disease Using Isolated Rat Brain Mitochondria | en |
| Type | Original Article | en |