Effects of Once-Weekly Dulaglutide on Glycemic Control and Renal Function in Patients with Advanced-Stage Diabetic Nephropathy
| Author | Keiji Hirai | en |
| Author | Shigeki Imamura | en |
| Author | Susumu Ookawara | en |
| Author | Aizan Hirai | en |
| Author | Yoshiyuki Morishita | en |
| Issued Date | 2017-09-30 | en |
| Abstract | Objectives: Dulaglutide and liraglutide are glucagon-like peptide-1 receptor agonists. We investigated the effects of once-weekly dulaglutide on glycemic control and renal function compared to once-daily liraglutide in patients with advanced-stage diabetic nephropathy. Methods: Changes over a 12-month period in levels of glycated hemoglobin, urine protein/creatinine ratio, and annual change in estimated glomerular filtration rate were retrospectively analyzed in 10 patients with advanced-stage diabetic nephropathy after changing from once-daily liraglutide (0.9 mg/day) to once-weekly dulaglutide (0.75 mg/week) (dulaglutide group). The control group comprised 10 patients with advanced-stage diabetic nephropathy who had continued once-daily liraglutide (0.9 mg/day) (liraglutide group). Results: The glycated hemoglobin level significantly decreased in the dulaglutide group after switching from liraglutide to dulaglutide (-0.81 ± 1.03% at 12 months from baseline, P < 0.05), but no change occurred in the liraglutide group. The urine protein/creatinine ratio and annual change in estimated glomerular filtration rate did not change in either groups. Conclusions: Once-weekly dulaglutide may be more advantageous for glycemic control compared to once-daily liraglutide in patients with advanced-stage diabetic nephropathy. | en |
| DOI | https://doi.org/10.5812/numonthly.55058 | en |
| Keyword | Advanced-Stage Diabetic Nephropathy | en |
| Keyword | Glucagon-Like Peptide-1 Receptor Agonist | en |
| Keyword | Dulaglutide | en |
| Keyword | Liraglutide | en |
| Publisher | Brieflands | en |
| Title | Effects of Once-Weekly Dulaglutide on Glycemic Control and Renal Function in Patients with Advanced-Stage Diabetic Nephropathy | en |
| Type | Research Article | en |
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