Antitussive Effect of Rosa damascena in Guinea pigs
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Abstract
Several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal andchest pain and strengthening the heart have been described for the flowers of Rosa damascena.North American Indian tribes use a decoction of the roots obtained from the Rosa damascenaplant as a cough remedy and to treat eye problem. Therefore, in the present study the antitussiveeffect of this plant in guinea pigs was evaluated. The antitussive effect of aerosols of two differ-ent concentrations of ethanolic extract (5 and10% w/v), aqueous extract (10 and 20% w/v),codeine, and saline were tested counting the number of cough produced due to aerosol of citricacid 10 min after exposing animal to aerosols of different solutions (n=6 for each solution). Theresults showed a significant reduction in the number of coughs obtained in the presence of bothconcentrations of ethanolic extract, higher co ncentrations of aqueous extract and codeine(P