The Inhibitory Effects of Ascorbic Acid, α-Tocopherol, and Sodium Selenite on Proliferation of Breast Cancer Cell Lines
| Author | Ebrahim Azizi | en |
| Author | Shahram Shoaibi | en |
| Author | Gabriele Ludewige | en |
| Author | Mohammad Reza Oveisi | en |
| Issued Date | 2003-07-31 | en |
| Abstract | The role of antioxidants in prevention and treatment of cancers have been reported by several studies. In our investigation we studied the effects of ascorbic acid, α-tocopherol, and sodium selenite on proliferation of two breast cancer cell lines: T47D (estrogen-receptor positive) and MDA-MB-231 (estrogen-receptor negative). We also used 17-β-estradiol as positive control for proliferation of T47D cells. The viability of cells after 7 days of exposure to different concentrations of test compounds was determined by resazurine based method. Ascorbic acid and α-tocopherol significantly inhibited cell growth at a concentration of 10-4 M in both cell lines and antagonized the cell proliferation induced by 17-β-estradiol in T47D cells. Sodium selenite at concentrations above 10-6 M strongly inhibited the cell growth in both cell lines and suppressed the stimulated growth of T47D cells by 17-β-estradiol. Our results with different strengths of activity of test compounds, further confirmed the findings of previous studies that showed the inhibitory effects of these antioxidants on other malignant cell lines. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.45 | en |
| Keyword | α-Tocopherol | en |
| Keyword | Antioxidants | en |
| Keyword | Breast Cancer | en |
| Keyword | T47D cells | en |
| Keyword | Cell proliferation | en |
| Keyword | Ascorbic acid | en |
| Keyword | Sodium selenite | en |
| Publisher | Brieflands | en |
| Title | The Inhibitory Effects of Ascorbic Acid, α-Tocopherol, and Sodium Selenite on Proliferation of Breast Cancer Cell Lines | en |
| Type | Research Article_csv_imported | en |
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