Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
| Author | Ardeshir Arzi | en |
| Author | Behnam Ghorbanzadeh | en |
| Author | Zahra Nazari Khorasgani | en |
| Issued Date | 2013-02-13 | en |
| Abstract | Background: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. Objectives: To investigate the antinociceptive activity of Iranian green tea extract. Materials and Methods: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection. Results: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. Conclusions: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways. | en |
| DOI | https://doi.org/10.17795/jjnpp-7404 | en |
| Keyword | Green Tea | en |
| Keyword | Antinociception | en |
| Keyword | Formalin Test | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats | en |
| Type | Research Article | en |