Synthesis, Radiolabeling and Biological Evaluation of <sup>99m</sup>Tc-labeled Deoxyglucose Derivatives for Molecular Imaging
| Author | Masoud Sadeghzadeh | en |
| Author | Ghorbanali Charkhlooiea | en |
| Author | Fariba Johari Daha | en |
| Issued Date | 2013-07-31 | en |
| Abstract | Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [99mTc(H2O)3(CO)3]+ complex. [99mTc]-ECB-DG and [99mTc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na99mTcO4 in 1 mL saline. Radio-HPLC analysis of [99mTc]- ECB-DG at pH = 7.4, revealed that labeling with 99mTc leads to formation of one radiochemical species with tR = 381 second. Three radiochemical species, Na99mTcO4, [99mTc]-DHP-DG and [99mTc(H2O)3(CO)3]+ complexes with tR = 342 sec, tR = 567 sec and tR = 1586 sec respectively, were obtained when [99mTc]-DHP-DG complex evaluated by HPLC. Biodistribution of two complexes were studied on normal mice at 10, 30 and 60 min post-injections. Compared to the 18F-FDG, [99mTc]-ECB-DG displayed a 2.8-fold reduction in brain uptake (1.7 ± 0.2 versus 0.61% ± 0.09) ,whereas [99mTc]-DHP-DG just showed 1.9-fold reduction in heart uptake (2.2 ± 0.05 towards 1.16±0.10) at 1 h post-injection. On the basis of our results, it seems that ECB-DG and DHP-DG analogues could be used as brain and heart imaging agent respectively. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1372 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125672 | en |
| Keyword | <sup>99m</sup>Tc | en |
| Keyword | Radiopharmaceuticals | en |
| Keyword | Glucosamine derivatives | en |
| Keyword | <sup>99m</sup>Tc-tricarbonyl complex | en |
| Keyword | Molecular imaging | en |
| Publisher | Brieflands | en |
| Title | Synthesis, Radiolabeling and Biological Evaluation of <sup>99m</sup>Tc-labeled Deoxyglucose Derivatives for Molecular Imaging | en |
| Type | Original Article | en |
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