peripheral blood leukocytes of mouse Effects of somatic extract and culture filtrate of fusarium solani on

Abstract

¯Abstract Background: The effect of somatic extract and culture filtrate of fusarium solani on peripheral blood leukocyte could be used in pharmacological studies. Objective: The aim of this study was to determine the effect of somatic and culture filtrate of fusarium solani on peripheral blood leukocytes counts in mouse. Methods: Fusarium solani strains UAMH7419 and UAMH3317 were used to prepare the somatic extract and culture filtrate. These substances with or without adjuvant, were injected intraperitoneally. Peripheral blood leukocytes count was then carried out and data were analyzed using non-parametric Mann-Whitney test. Findings: The somatic extract and filtrate culture of F. solani strains UAMH3317 and UAMH7419 induced leukocytosis and lymphocytosis in mouse. Conclusion: Leukocytosis producing effect of fusarium solani strains UAMH7419 and UAMH3317 could be used for therapeutic purposes especially in those with leukopenia although more studies are needed.