The Role of Serum Interleukin-6 Levels in Prognosticating Postoperative Complications After Cytoreductive Surgery for Ovarian Cancers: A Prospective Observational Study

Abstract

Background: Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been associated with adverse prognosis in ovarian cancer. Cytoreductive surgery for ovarian cancer has a higher risk of postoperative surgical complications (POCs). We aimed to find out if serum IL-6 is elevated preoperatively in patients undergoing cytoreductive surgery for ovarian cancer and if it can predict POCs. We also compared its trend with serum C-reactive protein (CRP) in the early postoperative period. Materials and Methods: Fifty-one patients between 18?75 years, posted for elective ovarian cytoreductive surgery at a tertiary cancer hospital were included after taking informed consent. Serum IL-6 and CRP were done the day before surgery and repeated 24 and 72 hours post-surgery. All parameters that affect POCs were captured. POCs were graded using the Clavein Dindo classification. We recorded the length of the intensive care unit (ICU), hospital stay, and 30-day mortality. Appropriate statistical tests were used and p value