Multivesicular Liposome (Depofoam) in Human Diseases
| Author | Bahare Salehi | en |
| Author | Abhay P. Mishra | en |
| Author | Manisha Nigam | en |
| Author | Farzad Kobarfard | en |
| Author | Zeeshan Javed | en |
| Author | Sadegh Rajabi | en |
| Author | Khushbukhat Khan | en |
| Author | Hafiz Ahsan Ashfaq | en |
| Author | Toqeer Ahmad | en |
| Author | Raffaele Pezzani | en |
| Author | Karina Ramírez-Alarcón | en |
| Author | Miquel Martorell | en |
| Author | William C. Cho | en |
| Author | Seyed Abdulmajid Ayatollahi | en |
| Author | Javad Sharifi-Rad | en |
| Issued Date | 2020-04-30 | en |
| Abstract | Drug development is a key point in the research of new therapeutic treatments for increasing maximum drug loading and prolonged drug effect. Encapsulation of drugs into multivesicular liposomes (DepoFoam) is a nanotechnology that allow delivery of the active constituent at a sufficient concentration during the entire treatment period. This guarantees the reduction of drug administration frequency, a very important factor in a prolonged treatment. Currently, diverse DepoFoam drugs are approved for clinical use against neurological diseases and for post-surgical pain management while other are under development for reducing surgical bleeding and for post-surgical analgesia. Also, on pre-clinical trials on cancer DepoFoam can improve bioavailability and stability of the drug molecules minimizing side effects by site-specific targeted delivery. In the current work, available literature on structure, preparation and pharmacokinetics of DepoFoam are reviewed. Moreover, we investigated approved DepoFoam formulations and preclinical studies with this nanotechnology. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.112291.13663 | en |
| URI | https://brieflands.com/journals/ijpr/articles/124653 | en |
| Keyword | DepoFoam | en |
| Keyword | Depocyt | en |
| Keyword | Encapsulation | en |
| Keyword | Nanotechnology | en |
| Keyword | Drugs | en |
| Publisher | Brieflands | en |
| Title | Multivesicular Liposome (Depofoam) in Human Diseases | en |
| Type | Review Article_imported | en |
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