Technetium-99m Tricarbonyl Labeled a Broad-spectrum Quinolone as a Specific Imaging Agent in Infection Diseases
| Author | Seyed Javad Khoramrouz | en |
| Author | Mostafa Erfani | en |
| Author | Mitra Athari Allaf | en |
| Issued Date | 2017-04-30 | en |
| Abstract | Nuclear medicine imaging has been used to localize infection sites, and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in-vivo use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice. Labeling yield of > 95% was obtained corresponding to a specific activity of 0.14 GBq/μmol. The radioconjugate showed good stability in human serum. Our main achievement was the high accumulation in the infected muscle in mice (T/NT = 2.93 ± 0.3 at 1 h post injection), which may diagnostically be beneficial for differentiate sites of infection from sites of inflammation. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2037 | en |
| Keyword | Infection | en |
| Keyword | <sup>99m</sup>Tc-carbonyl | en |
| Keyword | Gemifloxacin | en |
| Keyword | Quinolone | en |
| Keyword | Imaging | en |
| Publisher | Brieflands | en |
| Title | Technetium-99m Tricarbonyl Labeled a Broad-spectrum Quinolone as a Specific Imaging Agent in Infection Diseases | en |
| Type | Original Article | en |
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