Design, Synthesis and Anti-Tubercular Activity of Novel 1, 4-Dihydropyrine-3, 5-Dicarboxamide Containing 4(5)-Chloro-2-Ethyl- 5(4)-Imidazolyl Moiety
| Author | Maryam Iman | en |
| Author | Asghar Davood | en |
| Author | Mahboubeh Lotfinia | en |
| Author | Golnoush Dehqani | en |
| Author | Soroush Sardari | en |
| Author | Parisa Azerang | en |
| Author | Mohsen Amini | en |
| Issued Date | 2016-10-31 | en |
| Abstract | Current researches have showed that N3, N5-diaryl-2, 6-dimethyl -1, 4-dihydropyrine-3, 5- dicarboxamide analogues demonstrate notable anti-tubercular activity. In this study, Hantzsch condensation was used to design and synthesize new analogues of dihydropyridine (DHP). Different diary carboxamides were inserted at positions 3 and 5 of the DHP ring. 4(5)-chloro-2-ethyl-5(4)-imidazolyl moiety was considered at position 4 of the DHP ring. The structures of prepared ligands were characterized using TLC followed by FT-IR, elemental analysis, Mass and proton NMR. Results of anti-tubercular activity have indicated all the prepared ligands 3a-f inhibit the mycobacterium tuberculosis growth and the most potent compounds were 3c (3,4-Cl) and 3b (4-Cl). The in-vitro obtained data are agreement with our computational predictions in terms of partial atomic charge of carbonyl moieties at the positions 3 and 5 of dihydropyridine ring and the logP of the molecules. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1932 | en |
| Keyword | Dihydropyridine | en |
| Keyword | Mycobaterium | en |
| Keyword | Tuberculosis | en |
| Keyword | Imidazole | en |
| Publisher | Brieflands | en |
| Title | Design, Synthesis and Anti-Tubercular Activity of Novel 1, 4-Dihydropyrine-3, 5-Dicarboxamide Containing 4(5)-Chloro-2-Ethyl- 5(4)-Imidazolyl Moiety | en |
| Type | Original Article | en |
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