Efficacy of Atorvastatin Plus Aspirin in Comparison with Atorvastatin Alone on Liver Function and Degree of Fibrosis in Patients with Cryptogenic Cirrhosis: A Randomized Double-Blind Clinical Trial
| Author | Mohammad Reza Ghadir | en |
| Author | Seyed Saeed Sarkeshikian | en |
| Author | Ahmad Hormati | en |
| Author | Faezeh Alemi | en |
| Author | Pezhman Alavinejad | en |
| Author | Maryam Jameshorani | en |
| Author | Mansoureh Molaei | en |
| Author | Mahdi Jahangiry | en |
| Orcid | Mohammad Reza Ghadir [0000-0001-5674-3477] | en |
| Orcid | Seyed Saeed Sarkeshikian [0000-0002-5702-7410] | en |
| Orcid | Ahmad Hormati [0000-0002-1322-1318] | en |
| Orcid | Faezeh Alemi [0000-0002-0636-4847] | en |
| Orcid | Pezhman Alavinejad [0000-0001-6857-6151] | en |
| Orcid | Maryam Jameshorani [0000-0003-4223-7973] | en |
| Orcid | Mansoureh Molaei [0000-0002-7959-8337] | en |
| Orcid | Mahdi Jahangiry [0000-0002-2042-8974] | en |
| Issued Date | 2019-11-30 | en |
| Abstract | Objectives: This study was conducted to evaluate the efficacy of a combination therapy using aspirin (also known as acetylsalicylic acid (ASA)) and atorvastatin in comparison with atorvastatin alone to improve liver fibrosis and function in patients with cryptogenic cirrhosis. Methods: In this randomized double-blinded clinical trail, 40 patients with cryptogenic cirrhosis were randomly allocated to the intervention group (atorvastatin + ASA) and the control group (atorvastatin) treated for six months. Then liver function and stiffness (based on transient electrography) were compared. A checklist was used for data collection and the results were analyzed by SPSS 24 using chi-square test and paired t-test at the 0.05 significance level. Results: A total of 33 cases, including16 patients in group A (atorvastatin + ASA) and 17 in group B (atorvastatin + placebo) with a mean age of 50.3 ± 11.2 and 47.9 ± 10.6 years and BMI of 30.7 ± 4.2 and 30.8± 3.1 in groups A and B, were studied, respectively. Twelve patients (75%) in group A and 14 cases (82%) in group B were male. Both groups were homogenized in terms of demographic information at baseline. A significant improvement in Child score (P = 0.001 and P = 0.002 for groups A and B, respectively) and liver stiffness (P < 0.0001 and P = 0.007 for groups A and B, respectively) were observed in both groups after the intervention, however there was no significant improvement in child score (P = 0.982) and liver stiffness (P = 0.611) in comparing both groups. Conclusions: Although atorvastatin is effective in improvement of liver fibrosis and function in cryptogenic cirrhosis, adding ASA cannot improve its effects. | en |
| DOI | https://doi.org/10.5812/hepatmon.92342 | en |
| Keyword | Cryptogenic Cirrhosis | en |
| Keyword | Atorvastatin | en |
| Keyword | Aspirin | en |
| Keyword | Liver Fibrosis | en |
| Keyword | Liver Stiffness | en |
| Publisher | Brieflands | en |
| Title | Efficacy of Atorvastatin Plus Aspirin in Comparison with Atorvastatin Alone on Liver Function and Degree of Fibrosis in Patients with Cryptogenic Cirrhosis: A Randomized Double-Blind Clinical Trial | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- hepatmon-19-11-92342.pdf
- Size:
- 121.27 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF