Dissolution Rate Enhancement of Clarithromycin Using Ternary Ground Mixtures: Nanocrystal Formation
| Author | Malihe Shahbaziniaz | en |
| Author | Seyed Mohsen Foroutan | en |
| Author | Noushin Bolourchian | en |
| Issued Date | 2013-10-31 | en |
| Abstract | Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight ratios of CLA: SLS: PVP were ground in a dry process by planetary ball mill using different grinding ball size. Following the dissolution rate study, physical properties of the best dissolved co-ground formulation was studied. The accelerated stability studies were also conducted on the co-ground formulation. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1369 | en |
| Keyword | Clarithromycin | en |
| Keyword | Nanocrystals | en |
| Keyword | Co-ground mixture | en |
| Keyword | Dissolution rate | en |
| Publisher | Brieflands | en |
| Title | Dissolution Rate Enhancement of Clarithromycin Using Ternary Ground Mixtures: Nanocrystal Formation | en |
| Type | Original Article | en |
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