Is Elevated Mean Corpuscular Hemoglobin Concentration Valuable for Neonatal Hereditary Spherocytosis Screening?
| Author | Masoud Dehdashtian | en |
| Author | Mohammadreza Aramesh | en |
| Author | Arash Malakian | en |
| Author | Mohammadhassan Aletayeb | en |
| Author | Mohammadhassan Aletayeb 1 | en |
| Issued Date | 2013-08-31 | en |
| Abstract | Introduction:: The elevated Mean Corpuscular Hemoglobin Concentration (MCHC) were reported in neonates with hereditary spherocytosis. Aims: The aim of this study was to assess the reliability of elevated MCHC as a screening test for the diagnosis of hereditary spherocytosis in newborns. Methods and Material:: We revised records of 1301 neonates with diagnosis of severe hyperbilirubinemia from September 23, 2009 to September 22, 2011. The cases with MCHC ≥ 36g% were selected. Osmotic fragility test and cell blood counts were performed for cases that were enrolled in the study. Statistical analysis used: Statistical analyses were performed using Statistical Package for Social Sciences, version 15.0 (SPSS, Inc., , , ). Chi-square test and T-correlation analysis were used for statistical analysis Results: Out of a total 1301neonates with severe hyperbilirubinemia, 59 of them had MCHC ≥ 36 g%. Fifty two of 59 selected neonates were finally studied. All of them had MCHC ≤ 35.7g% and a normal osmotic fragility test. Conclusions: Elevated MCHC is not a reliable screening test for the diagnosis of hereditary spherocytosis in neonates with severe hyperbilirubinemia or anemia. | en |
| DOI | https://doi.org/ | en |
| Publisher | Brieflands | en |
| Title | Is Elevated Mean Corpuscular Hemoglobin Concentration Valuable for Neonatal Hereditary Spherocytosis Screening? | en |
| Type | Research Article | en |
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